Emerging therapeutic strategies to enhance HDL function
نویسندگان
چکیده
منابع مشابه
Strategies to promote HDL-C: an emerging therapeutic target.
Hydroxy-methyl glutaryl coenzyme A reductase inhibitors (statins) have accumulated an extraordinary record of successful randomized clinical trials, transforming the practice of preventive cardiology. However, most placebo-controlled statin trials have reported not more than 25–35% reduction in morbidity/mortality during 5 year follow-up. Thus, despite their established benefits in primary and ...
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It has long been recognized that elevated levels of low-density lipoprotein cholesterol (LDL-C) increase the risk of cardiovascular disease (CHD) and that pharmacologic therapy to decrease LDL-C significantly reduces cardiovascular events. Despite the effectiveness of statins for CHD risk reduction, even optimal LDL-lowering therapy alone fails to avert 60% to 70% of CHD cases. A low plasma con...
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ژورنال
عنوان ژورنال: Lipids in Health and Disease
سال: 2011
ISSN: 1476-511X
DOI: 10.1186/1476-511x-10-175